Adam Sandler as Count Dracula, the owner and hotel manager of Hotel Transylvania, and Mavis' over-protective father.
CeeLo Green as Murray the Mummy, one of Dracula's best friends who mostly hangs out with Frankenstein
David Spade as Griffin the Invisible Man, one of Dracula's best friends.
The Werewolf Kids are the children of Wayne and Wanda. With the exception of Winnie, they are a rowdy and ill-behaved bunch. Most of them appear to be male, but it is unknown just how many of them there are.
Martha plays only a small role as a character in Hotel Transylvania in order to allow the father-daughter dynamic to take center stage, but although she appears only briefly in photos and recollected memories, her existence affects the story profoundly.
Fran Drescher as Eunice, Frankenstein's wife and Wanda's best friend.
Molly Shannon as Wanda, a werewolf, Wayne's pregnant wife and Eunice's best friend.
Esmeralda is Quasimodo's pet rat and the secondary antagonist of the film. She is always accompanying the great chef.
Selena Gomez as Mavis, Dracula's 118-year-old "teenage" vampire daughter who likes humans and falls in love with Johnny.
Andy Samberg as Jonathan ("Johnnystein"), a 21-year-old human who stumbles onto Hotel Transylvania.
Steve Buscemi as Wayne, a werewolf who is also one of Dracula's best friends and the husband of Wanda.
Jon Lovitz as Quasimodo, a gourmet chef and the former Hunchback of Notre Dame who desires to make a dish with any human as the main ingredient.
Frankenstein's fear of fire is a reference to the 1931 Universal Studios film Frankenstein, where the same character is extremely fearful of fire, who ultimately is defeated in a burning windmill.